Tottenham full-back Davies dislocated a shoulder at Southampton last month while West Ham centre-back
Collins picked up a calf strain 10 days ago.
Both Davies and Collins featured in Wales' last qualifier - a 3-0 victory in Israel at the end of March - but
have failed to recover in time for the Group B top-of-the-table clash with
leaders Belgium at the Cardiff City Stadium
on June 12.
Jonathan Williams (groin), Emyr Huws (knee) and George
Williams (ankle) are also unavailable.
Wales manager Chris Coleman has named a 23-man squad in
which Real Madrid forward Gareth Bale and Arsenal
playmaker Aaron Ramsey both feature.
Leicester midfielder Andy King returns after serving a
two-match ban for his red card in the Euro 2016 qualifier against Cyprus last
October, while Newcastle defender Paul Dummett and Celtic's Adam Matthews are
included after injury.
Wales squad: Goalkeepers: Hennessey (Crystal Palace), Fon Williams (Tranmere), Ward (Liverpool).
Defenders: Williams (Swansea, capt), Chester (Hull), Gunter
(Reading), Taylor (Swansea), Dummett (Newcastle),
Matthews (Celtic), Richards (Swansea), Henley (Blackburn),
Midfielders: Allen (Liverpool), Ledley (Crystal Palace),
Ramsey (Arsenal), King (Leicester), Vaughan (Nottingham Forest), MacDonald (Bournemouth), Cotterill (Birmingham).
Strikers: Robson-Kanu (Reading), Lawrence (Leicester), Bale
(Real Madrid), Church (Charlton), Vokes (Burnley).
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