The research, published in the journal Proceedings of the National Academy of Sciences, followed 31 men ages 18 to 35.
Subjects filled out questionnaires about their general health and gave
blood samples. Men were then divided — 14 in an ibuprofen group, 17 in a
placebo group.
Ibuprofen subjects were given 600 mg twice a day, or the equivalent of three pills.
The team of investigators from Denmark, France and China found that
within two week these men had an elevated risk of compensated
hypogonadism, “a condition prevalent among elderly men and associated
with reproductive and physical disorders,” researchers note.
The condition,
known as testosterone deficiency, is a failure of the testes to produce
the male sex hormone testosterone, sperm or both. It is also associated
with depression and increased risk for cardiovascular events, including
heart failure and stroke.”
“It is sure that these effects are reversible," study author Bernard
Jégou, of the French National Institute of Health and Medical Research,told CNN.
However, it’s unknown whether the health effects of long-term ibuprofen use are reversible, he added.
The new study isn’t the first to suggest that ibuprofen has downsides.
In 2017, it was reported that the NSAID that goes by brand names
including Motrin and Advil raises the risk of heart attacks.
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