Research in 6 Months Into Worst Ebola Outbreak

 Six months into the biggest-ever Ebola outbreak, scientists say they know more about how the deadly virus behaves. The first cases were reported in Guinea by the World Health Organization on March 23 — before spreading to Sierra Leone, Liberia and elsewhere. Here's a look at what scientists have learned so far.

HOW DIFFERENT IS THIS OUTBREAK?

Past outbreaks have mostly been in remote, rural communities and have typically been snuffed out in weeks or months. But one main difference this time is that the virus has hit densely packed cities in West Africa, making the current outbreak an international threat.

"I always thought Ebola was really bad when it happens, but that it would kill 100 people in a remote part of Africa, and then it's over," said Dr. Peter Piot, the co-discoverer of Ebola. He said the severity of this outbreak could also be linked to the increased movement of people across borders and "more contact with whatever the primary source of Ebola is." The virus' reservoir is thought to be fruit bats, considered a delicacy in some parts of Africa.

In a study released Tuesday by the New England Journal of Medicine, the World Health Organization said there could be almost 21,000 Ebola cases by early November and that cases could continue to trickle out for years.

WILL THIS OUTBREAK JUST BURN ITSELF OUT?

Yes, but that's a worst case scenario. If control measures don't work, at some point, Ebola will have infected everyone who hasn't already been killed or recovered from the virus and there won't be enough people to maintain the virus' spread, said Dr. Bruce Aylward, WHO assistant director-general in charge of emergencies. He said the next few months are crucial to curbing transmission.

"As this outbreak continues, the sheer caseload will make it much more difficult to get people isolated and into beds," he said.

"The way Ebola has spread so far, it's hard to believe it will just die out," added Dr. Heinz Feldmann, chief of virology at the U.S. National Institute of Allergy and Infectious Disease. "At some point it will, but how long is that going to take and how many people have to die for that to happen?"

IS EBOLA BECOMING MORE INFECTIOUS?

We don't know. Experts say it's difficult to assess that in the current outbreak since so many issues are involved. It's possible the virus has become more infectious than before — which might explain the spiraling caseload — but it's also possible health workers aren't properly protected or are so overworked they are making more mistakes. There has also been more physical violence involving patients, many of whom are suspicious of Western aid workers. This has led to risky situations that might increase the chances of getting infected, said Michael Osterholm, a professor at the University of Minnesota who advises the U.S. government on infectious diseases. Scientists have also noted hundreds of mutations in the virus so far but aren't sure what that means, since viruses evolve constantly.