His absence was mocked by his rivals, who tried to fill the space
vacated by Mr Trump's boycott by attacking each other on immigration and
other issues.
Mr Trump decided to withdraw after Fox News refused to drop debate host Megyn Kelly, whom he accused of bias.
The billionaire held a rally nearby, in honour of war veterans, that threatened to overshadow the debate itself.
On Monday, voters in Iowa are due to pick their presidential nominee for each party.
Days
ahead of that critical test, Mr Trump's absence on the stage in Des
Moines was keenly felt by his seven rivals in the race to be Republican
presidential nominee.
Texas Senator Ted Cruz addressed it with humour in the opening minutes by throwing mock insults at his rivals.
"I'm a maniac and everyone on this stage is stupid, fat and ugly, and Ben [Carson], you're a terrible surgeon," he said.
Former
Florida Governor Jeb Bush also poked fun at the hotel tycoon, his chief
tormenter in previous debates, by saying how much he missed him.
The debate as it happened
Other highlights:
- Florida Senator Marco Rubio stood by a previous pledge to shut down mosques where radicalisation is taking place
- He also promised to tear up the nuclear deal with Iran on "day one" of being president
- Mr Cruz was booed when he accused the Fox presenters of encouraging attacks on him
- New Jersey Governor Chris Christie said he knew nothing about the infamous, politically-motivated traffic jam ordered by his aides
- Kentucky Senator Rand Paul raised concerns about the US expanding military role in Syria
Elsewhere in Des Moines at the same time, Mr Trump led a raucous rally in honour of the country's war veterans.
"When you're treated badly, you have to stick up for your rights," he said, referring to his row with Fox.
The broadcaster released a statement that said Mr Trump offered to
appear at the debate if Fox contributed $5m to his charities, but they
refused.
Data released by Google after the debate suggested that search interest in Mr Trump still far surpassed the other candidates.
Many observers on social media thought the event was duller without the brash New Yorker.
Some of the night's most heated moments were provided during exchanges about immigration.
Mr
Cruz and Mr Rubio were both forced to explain video clips of previous
statements that appeared to be at odds with their hardline campaign
pledges.
They then turned on each other, with Mr Rubio saying immigration was "the lie that Ted's campaign is built upon".
An
Iraq war veteran who came to the US from Mexico as a child appeared via
YouTube to tell the candidates that "some of the comments in this
campaign make us question our place in this country".
Mr Bush applauded Dulce Candy and said "we should be a welcoming nation".
The Iowa caucuses on Monday are seen as the first real test of the
election campaign, and the beginning of a series of state-by-state
contests to choose delegates for both Republicans and Democrats.
Unlike
a primary, which is a traditional election featuring secret ballots on
polling day, the caucuses in Iowa are meetings of registered party
voters and activists where they discuss the candidates and then vote.
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